Expanded B cell population blocks regulatory T cells and exacerbates ileitis in a murine model of Crohn disease

SAMP1/YitFc mice develop discontinuous, transmural inflammatory lesions in the terminal ileum, similar to what is found in human Crohn disease. Compared with the mesenteric lymph nodes (MLNs) of AKR control mice, SAMP1/YitFc MLNs contain a 4.3-fold expansion in total B cell number and a 2.5-fold inc...

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Hauptverfasser: Olson, Timothy S., Bamias, Giorgos, Naganuma, Makoto, Rivera-Nieves, Jesús, Burcin, Tracy L., Ross, William, Morris, Margaret A., Pizarro, Theresa T., Ernst, Peter B., Cominelli, Fabio, Ley, Klaus
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Clinical Investigation 2004
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC484978/
https://ncbi.nlm.nih.gov/pubmed/15286805
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI200420855
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