Expanded B cell population blocks regulatory T cells and exacerbates ileitis in a murine model of Crohn disease

SAMP1/YitFc mice develop discontinuous, transmural inflammatory lesions in the terminal ileum, similar to what is found in human Crohn disease. Compared with the mesenteric lymph nodes (MLNs) of AKR control mice, SAMP1/YitFc MLNs contain a 4.3-fold expansion in total B cell number and a 2.5-fold inc...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
मुख्य लेखकों: Olson, Timothy S., Bamias, Giorgos, Naganuma, Makoto, Rivera-Nieves, Jesús, Burcin, Tracy L., Ross, William, Morris, Margaret A., Pizarro, Theresa T., Ernst, Peter B., Cominelli, Fabio, Ley, Klaus
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: American Society for Clinical Investigation 2004
विषय:
Article
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC484978/
https://ncbi.nlm.nih.gov/pubmed/15286805
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI200420855
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