Addressing inaccuracies in BLOSUM computation improves homology search performance

BACKGROUND: BLOSUM matrices belong to the most commonly used substitution matrix series for protein homology search and sequence alignments since their publication in 1992. In 2008, Styczynski et al. discovered miscalculations in the clustering step of the matrix computation. Still, the RBLOSUM64 ma...

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Bibliografiske detaljer
Udgivet i:BMC Bioinformatics
Main Authors: Hess, Martin, Keul, Frank, Goesele, Michael, Hamacher, Kay
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2016
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4849092/
https://ncbi.nlm.nih.gov/pubmed/27122148
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12859-016-1060-3
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