BRCA1 positively regulates FOXO3 expression by restricting FOXO3 gene methylation and epigenetic silencing through targeting EZH2 in breast cancer

BRCA1 mutation or depletion correlates with basal-like phenotype and poor prognosis in breast cancer but the underlying reason remains elusive. RNA and protein analysis of a panel of breast cancer cell lines revealed that BRCA1 deficiency is associated with downregulation of the expression of the pl...

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Detalhes bibliográficos
Publicado no:Oncogenesis
Main Authors: Gong, C, Yao, S, Gomes, A R, Man, E P S, Lee, H J, Gong, G, Chang, S, Kim, S-B, Fujino, K, Kim, S-W, Park, S K, Lee, J W, Lee, M H, Khoo, U S, Lam, E W-F
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4848836/
https://ncbi.nlm.nih.gov/pubmed/27043660
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/oncsis.2016.23
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