Lovastatin causes FaDu hypopharyngeal carcinoma cell death via AMPK-p63-survivin signaling cascade

Statins are used widely to lower serum cholesterol and the incidence of cardiovascular diseases. Growing evidence shows that statins also exhibit beneficial effects against cancers. In this study, we investigated the molecular mechanisms involved in lovastatin-induced cell death in Fadu hypopharynge...

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Udgivet i:Sci Rep
Main Authors: Yen, Chia-Sheng, Chen, Jung-Chien, Chang, Yi-Fang, Hsu, Ya-Fen, Chiu, Pei-Ting, Shiue, Ching, Chuang, Yu-Fan, Ou, George, Hsu, Ming-Jen
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4848532/
https://ncbi.nlm.nih.gov/pubmed/27122225
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep25082
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