A Novel Hydroxamate-Based Compound WMJ-J-09 Causes Head and Neck Squamous Cell Carcinoma Cell Death via LKB1-AMPK-p38MAPK-p63-Survivin Cascade

Growing evidence shows that hydroxamate-based compounds exhibit broad-spectrum pharmacological properties including anti-tumor activity. However, the precise mechanisms underlying hydroxamate derivative-induced cancer cell death remain incomplete understood. In this study, we explored the anti-tumor...

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Detalhes bibliográficos
Publicado no:Front Pharmacol
Main Authors: Yen, Chia-Sheng, Choy, Cheuk-Sing, Huang, Wei-Jan, Huang, Shiu-Wen, Lai, Pin-Ye, Yu, Meng-Chieh, Shiue, Ching, Hsu, Ya-Fen, Hsu, Ming-Jen
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2018
Assuntos:
Pharmacology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5837967/
https://ncbi.nlm.nih.gov/pubmed/29545751
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2018.00167
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