MicroRNA-223 Attenuates Hypoxia-induced Vascular Remodeling by Targeting RhoB/MLC2 in Pulmonary Arterial Smooth Muscle Cells

There is growing evidence that microRNAs are implicated in pulmonary arterial hypertension (PAH), but underlying mechanisms remain elusive. Here, we identified that miR-223 was significantly downregulated in chronically hypoxic mouse and rat lungs, as well as in pulmonary artery and pulmonary artery...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Zeng, Yan, Zhang, Xiaoying, Kang, Kang, Chen, Jidong, Wu, Zhiqin, Huang, Jinyong, Lu, Wenju, Chen, Yuqin, Zhang, Jie, Wang, Zhiwei, Zhai, Yujia, Qu, Junle, Ramchandran, Ramaswamy, Raj, J. Usha, Wang, Jian, Gou, Deming
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4848472/
https://ncbi.nlm.nih.gov/pubmed/27121304
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep24900
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