Insights into the activation mechanism of class I HDAC complexes by inositol phosphates

Histone deacetylases (HDACs) 1, 2 and 3 form the catalytic subunit of several large transcriptional repression complexes. Unexpectedly, the enzymatic activity of HDACs in these complexes has been shown to be regulated by inositol phosphates, which bind in a pocket sandwiched between the HDAC and co-...

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Publicado no:Nat Commun
Main Authors: Watson, Peter J., Millard, Christopher J., Riley, Andrew M., Robertson, Naomi S., Wright, Lyndsey C., Godage, Himali Y., Cowley, Shaun M., Jamieson, Andrew G., Potter, Barry V. L., Schwabe, John W. R.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4848466/
https://ncbi.nlm.nih.gov/pubmed/27109927
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms11262
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