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Glutathione biosynthesis is a metabolic vulnerability in PI3K/Akt-driven breast cancer
Cancer cells often select for mutations that enhance signaling through pathways that promote anabolic metabolism(1). Although the PI3K/Akt signaling pathway, which is frequently dysregulated in breast cancer(2), is a well-established regulator of central glucose metabolism and aerobic glycolysis(3,4...
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| Gepubliceerd in: | Nat Cell Biol |
|---|---|
| Hoofdauteurs: | , , , , , , |
| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
2016
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4848114/ https://ncbi.nlm.nih.gov/pubmed/27088857 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncb3341 |
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