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Antiproliferative and proapoptotic effects of a pyrrole containing arylthioindole in human Jurkat leukemia cell line and multidrug-resistant Jurkat/A4 cells

Recently, a series of novel arylthioindole compounds, potent inhibitors of tubulin polymerization and cancer cell growth, were synthesized. In the present study the effects of 2-(1H-pyrrol-3-yl)-3-((3,4,5-trimethoxyphenyl)thio)-1H-indole (ATI5 compound) on cell proliferation, cell cycle progression,...

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Bibliografiske detaljer
Udgivet i:Cancer Biol Ther
Main Authors: Philchenkov, Alex A, Zavelevich, Michael P, Tryndyak, Volodymyr P, Kuiava, Ludmila M, Blokhin, Dmitry Yu, Miura, Koh, Silvestri, Romano, Pogribny, Igor P
Format: Artigo
Sprog:Inglês
Udgivet: Taylor & Francis 2016
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4847820/
https://ncbi.nlm.nih.gov/pubmed/26785947
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15384047.2015.1078026
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