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Sphingosine kinase inhibitors decrease viability and induce cell death in natural killer-large granular lymphocyte leukemia
Sphingolipid metabolism has been identified as a potential therapeutic target in cancer. Sphingosine-1-phosphate (S1P) is a potent bioactive sphingolipid metabolite produced by sphingosine kinases-1 and −2 (SPHK1 and SPHK2). Elevated SPHK1 has been found in numerous cancer types and been shown to co...
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| 出版年: | Cancer Biol Ther |
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| 主要な著者: | , , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Taylor & Francis
2015
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4847818/ https://ncbi.nlm.nih.gov/pubmed/26252351 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15384047.2015.1078949 |
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