Sphingosine kinase inhibitors decrease viability and induce cell death in natural killer-large granular lymphocyte leukemia

Sphingolipid metabolism has been identified as a potential therapeutic target in cancer. Sphingosine-1-phosphate (S1P) is a potent bioactive sphingolipid metabolite produced by sphingosine kinases-1 and −2 (SPHK1 and SPHK2). Elevated SPHK1 has been found in numerous cancer types and been shown to co...

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Veröffentlicht in:Cancer Biol Ther
Hauptverfasser: LeBlanc, Francis R, Liu, Xin, Hengst, Jeremy, Fox, Todd, Calvert, Valerie, Petricoin, Emanuel F, Yun, Jong, Feith, David J, Loughran, Thomas P
Format: Artigo
Sprache:Inglês
Veröffentlicht: Taylor & Francis 2015
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4847818/
https://ncbi.nlm.nih.gov/pubmed/26252351
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15384047.2015.1078949
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