A bivalent recombinant immunotoxin with high potency against tumors with EGFR and EGFRvIII expression

EGFR and EGFRvIII are overexpressed in various types of cancer, serving as optimal targets for cancer therapy. Capitalizing on the high specificity of humanized antibody 806 (mAb806) to the EGFR and EGFRvIII overexpressed in cancer, we designed and generated a bivalent recombinant immunotoxin (RIT,...

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Dettagli Bibliografici
Pubblicato in:Cancer Biol Ther
Autori principali: Meng, Jie, Liu, Yuanyi, Gao, Shuying, Lin, Stephen, Gu, Xinbin, Pomper, Martin G, Wang, Paul C, Shan, Liang
Natura: Artigo
Lingua:Inglês
Pubblicazione: Taylor & Francis 2015
Soggetti:
Research Paper
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4847807/
https://ncbi.nlm.nih.gov/pubmed/26467217
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15384047.2015.1095403
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