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Mechanistic Investigation of cPMP Synthase in Molybdenum Cofactor Biosynthesis Using an Uncleavable Substrate Analogue

Molybdenum cofactor (Moco) is essential for all kingdoms of life, plays central roles in various biological processes, and must be biosynthesized de novo. During its biosynthesis, the characteristic pyranopterin ring is constructed by a complex rearrangement of guanosine 5′-triphosphate (GTP) into c...

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Detalhes bibliográficos
Publicado no:Biochemistry
Main Authors: Hover, Bradley M., Lilla, Edward A., Yokoyama, Kenichi
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4847533/
https://ncbi.nlm.nih.gov/pubmed/26575208
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.5b00857
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