LPS-induced NFκB enhanceosome requires TonEBP/NFAT5 without DNA binding

NFκB is a central mediator of inflammation. Present inhibitors of NFκB are mostly based on inhibition of essential machinery such as proteasome and protein kinases, or activation of nuclear receptors; as such, they are of limited therapeutic use due to severe toxicity. Here we report an LPS-induced...

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Veröffentlicht in:Sci Rep
Hauptverfasser: Lee, Hwan Hee, Sanada, Satoru, An, Seung Min, Ye, Byeong Jin, Lee, Jun Ho, Seo, Young-Kyo, Lee, Changwook, Lee-Kwon, Whaseon, Küper, Christoph, Neuhofer, Wolfgang, Choi, Soo Youn, Kwon, Hyug Moo
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2016
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4847014/
https://ncbi.nlm.nih.gov/pubmed/27118681
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep24921
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