Microglial TonEBP mediates LPS-induced inflammation and memory loss as transcriptional cofactor for NF-κB and AP-1

BACKGROUND: Microglia are brain-resident myeloid cells involved in the innate immune response and a variety of neurodegenerative diseases. In macrophages, TonEBP is a transcriptional cofactor of NF-κB which stimulates the transcription of pro-inflammatory genes in response to LPS. Here, we examined...

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Bibliographic Details
Published in:J Neuroinflammation
Main Authors: Jeong, Gyu Won, Lee, Hwan Hee, Lee-Kwon, Whaseon, Kwon, Hyug Moo
Format: Artigo
Language:Inglês
Published: BioMed Central 2020
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Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7722447/
https://ncbi.nlm.nih.gov/pubmed/33292328
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12974-020-02007-9
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