Targeting drug transport mechanisms for improving platinum-based cancer chemotherapy

INTRODUCTION: Platinum (Pt)-based antitumor agents remain important chemotherapeutic agents for treating many human malignancies. Elevated expression of the human high-affinity copper transporter 1 (hCtr1), resulting in enhanced Pt drug transport into cells, has been shown to be associated with impr...

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Detalhes bibliográficos
Publicado no:Expert Opin Ther Targets
Main Authors: Chen, Helen HW, Chen, Wen-Chung, Liang, Zhang-Dong, Tsai, Wen-Bin, Long, Yan, Aiba, Isamu, Fu, Siqing, Broaddus, Russell, Liu, Jinsong, Feun, Lynn G, Savaraj, Niramol, Kuo, Macus Tien
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4846984/
https://ncbi.nlm.nih.gov/pubmed/26004625
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1517/14728222.2015.1043269
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