A single active catalytic site is sufficient to promote transport in P-glycoprotein

P-glycoprotein (Pgp) is an ABC transporter responsible for the ATP-dependent efflux of chemotherapeutic compounds from multidrug resistant cancer cells. Better understanding of the molecular mechanism of Pgp-mediated transport could promote rational drug design to circumvent multidrug resistance. By...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Bársony, Orsolya, Szalóki, Gábor, Türk, Dóra, Tarapcsák, Szabolcs, Gutay-Tóth, Zsuzsanna, Bacsó, Zsolt, Holb, Imre J., Székvölgyi, Lóránt, Szabó, Gábor, Csanády, László, Szakács, Gergely, Goda, Katalin
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4846820/
https://ncbi.nlm.nih.gov/pubmed/27117502
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep24810
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