RSK3 is required for concentric myocyte hypertrophy in an activated Raf1 model for Noonan syndrome

Noonan syndrome (NS) is a congenital disorder resulting from mutations of the Ras-Raf signaling pathway. Hypertrophic cardiomyopathy associated with RAF1 “RASopathy” mutations is a major risk factor for heart failure and death in NS and has been attributed to activation of MEK1/2-ERK1/2 mitogen-acti...

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Veröffentlicht in:J Mol Cell Cardiol
Hauptverfasser: Passariello, Catherine L., Martinez, Eliana C., Thakur, Hrishikesh, Cesareo, Maria, Li, Jinliang, Kapiloff, Michael S.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2016
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4846495/
https://ncbi.nlm.nih.gov/pubmed/26940993
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.yjmcc.2016.02.020
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