Calcineurin Aβ-Specific Anchoring Confers Isoform-Specific Compartmentation and Function in Pathological Cardiac Myocyte Hypertrophy

BACKGROUND: The Ca(2+)/calmodulin-dependent phosphatase calcineurin is a key regulator of cardiac myocyte hypertrophy in disease. An unexplained paradox is how the Aβ isoform of calcineurin (CaNAβ) is required for induction of pathological myocyte hypertrophy, despite calcineurin Aα expression in th...

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Bibliografiska uppgifter
I publikationen:Circulation
Huvudupphovsmän: Li, Xiaofeng, Li, Jinliang, Martinez, Eliana C., Froese, Alexander, Passariello, Catherine L., Henshaw, Kathryn, Rusconi, Francesca, Li, Yang, Yu, Qian, Thakur, Hrishikesh, Nikolaev, Viacheslav O., Kapiloff, Michael S.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2020
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC7484230/
https://ncbi.nlm.nih.gov/pubmed/32611257
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCULATIONAHA.119.044893
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