Calcineurin Aβ-Specific Anchoring Confers Isoform-Specific Compartmentation and Function in Pathological Cardiac Myocyte Hypertrophy

BACKGROUND: The Ca(2+)/calmodulin-dependent phosphatase calcineurin is a key regulator of cardiac myocyte hypertrophy in disease. An unexplained paradox is how the Aβ isoform of calcineurin (CaNAβ) is required for induction of pathological myocyte hypertrophy, despite calcineurin Aα expression in th...

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Publicado en:Circulation
Main Authors: Li, Xiaofeng, Li, Jinliang, Martinez, Eliana C., Froese, Alexander, Passariello, Catherine L., Henshaw, Kathryn, Rusconi, Francesca, Li, Yang, Yu, Qian, Thakur, Hrishikesh, Nikolaev, Viacheslav O., Kapiloff, Michael S.
Formato: Artigo
Idioma:Inglês
Publicado: 2020
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7484230/
https://ncbi.nlm.nih.gov/pubmed/32611257
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCULATIONAHA.119.044893
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