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Calcineurin Aβ-Specific Anchoring Confers Isoform-Specific Compartmentation and Function in Pathological Cardiac Myocyte Hypertrophy

BACKGROUND: The Ca(2+)/calmodulin-dependent phosphatase calcineurin is a key regulator of cardiac myocyte hypertrophy in disease. An unexplained paradox is how the Aβ isoform of calcineurin (CaNAβ) is required for induction of pathological myocyte hypertrophy, despite calcineurin Aα expression in th...

詳細記述

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書誌詳細
出版年:Circulation
主要な著者: Li, Xiaofeng, Li, Jinliang, Martinez, Eliana C., Froese, Alexander, Passariello, Catherine L., Henshaw, Kathryn, Rusconi, Francesca, Li, Yang, Yu, Qian, Thakur, Hrishikesh, Nikolaev, Viacheslav O., Kapiloff, Michael S.
フォーマット: Artigo
言語:Inglês
出版事項: 2020
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC7484230/
https://ncbi.nlm.nih.gov/pubmed/32611257
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCULATIONAHA.119.044893
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