Calcineurin Aβ-Specific Anchoring Confers Isoform-Specific Compartmentation and Function in Pathological Cardiac Myocyte Hypertrophy

BACKGROUND: The Ca(2+)/calmodulin-dependent phosphatase calcineurin is a key regulator of cardiac myocyte hypertrophy in disease. An unexplained paradox is how the Aβ isoform of calcineurin (CaNAβ) is required for induction of pathological myocyte hypertrophy, despite calcineurin Aα expression in th...

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Vydáno v:Circulation
Hlavní autoři: Li, Xiaofeng, Li, Jinliang, Martinez, Eliana C., Froese, Alexander, Passariello, Catherine L., Henshaw, Kathryn, Rusconi, Francesca, Li, Yang, Yu, Qian, Thakur, Hrishikesh, Nikolaev, Viacheslav O., Kapiloff, Michael S.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2020
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7484230/
https://ncbi.nlm.nih.gov/pubmed/32611257
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCULATIONAHA.119.044893
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