MOUSE MODELS FOR ASSESSING PROTEIN IMMUNOGENICITY: LESSONS AND CHALLENGES

The success of clinical and commercial therapeutic proteins is rapidly increasing, but their potential immunogenicity is an ongoing concern. Most of the studies that have been conducted over the past few years to examine the importance of various product-related attributes (in particular several typ...

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Veröffentlicht in:J Pharm Sci
Hauptverfasser: Jiskoot, Wim, Kijanka, Grzegorz, Randolph, Theodore W., Carpenter, John F., Koulov, Atanas, Mahler, Hanns-Christian, Joubert, Marisa K., Jawa, Vibha, Narhi, Linda O.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2016
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4846475/
https://ncbi.nlm.nih.gov/pubmed/27044944
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.xphs.2016.02.031
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