Targeted inhibition of the deubiquitinating enzymes, USP14 and UCHL5, induces proteotoxic stress and apoptosis in Waldenström macroglobulinaemia tumour cells

Deubiquitinase enzymes (DUBs) of the proteasomal 19S regulatory particle are emerging as important therapeutic targets in several malignancies. Here we demonstrate that inhibition of two proteasome-associated DUBs (USP14 and UCHL5) with the small molecule DUB inhibitor b-AP15, results in apoptosis o...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Br J Haematol
Main Authors: Chitta, Kasyapa, Paulus, Aneel, Akhtar, Sharoon, Blake, Maja Kristin K., Caulfield, Thomas R., Novak, Anne J., Ansell, Stephen M., Advani, Pooja, Ailawadhi, Sikander, Sher, Taimur, Linder, Stig, Chanan-Khan, Asher
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4846423/
https://ncbi.nlm.nih.gov/pubmed/25691154
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bjh.13304
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados