Targeted inhibition of the deubiquitinating enzymes, USP14 and UCHL5, induces proteotoxic stress and apoptosis in Waldenström macroglobulinaemia tumour cells

Deubiquitinase enzymes (DUBs) of the proteasomal 19S regulatory particle are emerging as important therapeutic targets in several malignancies. Here we demonstrate that inhibition of two proteasome-associated DUBs (USP14 and UCHL5) with the small molecule DUB inhibitor b-AP15, results in apoptosis o...

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Pubblicato in:Br J Haematol
Autori principali: Chitta, Kasyapa, Paulus, Aneel, Akhtar, Sharoon, Blake, Maja Kristin K., Caulfield, Thomas R., Novak, Anne J., Ansell, Stephen M., Advani, Pooja, Ailawadhi, Sikander, Sher, Taimur, Linder, Stig, Chanan-Khan, Asher
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2015
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4846423/
https://ncbi.nlm.nih.gov/pubmed/25691154
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bjh.13304
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