Targeted inhibition of the deubiquitinating enzymes, USP14 and UCHL5, induces proteotoxic stress and apoptosis in Waldenström macroglobulinaemia tumour cells

Deubiquitinase enzymes (DUBs) of the proteasomal 19S regulatory particle are emerging as important therapeutic targets in several malignancies. Here we demonstrate that inhibition of two proteasome-associated DUBs (USP14 and UCHL5) with the small molecule DUB inhibitor b-AP15, results in apoptosis o...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Br J Haematol
Prif Awduron: Chitta, Kasyapa, Paulus, Aneel, Akhtar, Sharoon, Blake, Maja Kristin K., Caulfield, Thomas R., Novak, Anne J., Ansell, Stephen M., Advani, Pooja, Ailawadhi, Sikander, Sher, Taimur, Linder, Stig, Chanan-Khan, Asher
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2015
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4846423/
https://ncbi.nlm.nih.gov/pubmed/25691154
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bjh.13304
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