Targeting CD38 with daratumumab is lethal to Waldenström macroglobulinaemia cells

CD38 is expressed on Waldenström macroglobulinaemia (WM) cells, but its role as a therapeutic target remains undefined. With recent approval of the anti-CD38 monoclonal antibody, daratumumab (Dara), we hypothesized that blocking CD38 would be lethal to WM cells. In vitro Dara treatment of WM cells (...

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Détails bibliographiques
Publié dans:Br J Haematol
Auteurs principaux: Paulus, Aneel, Manna, Alak, Akhtar, Sharoon, Paulus, Shumail M., Sharma, Mayank, Coignet, Marie V., Jiang, Liuyan, Roy, Vivek, Witzig, Thomas E., Ansell, Stephen M., Allan, John, Furman, Richard, Aulakh, Sonikpreet, Manochakian, Rami, Ailawadhi, Sikander, Chanan-Khan, Asher A., Sher, Taimur
Format: Artigo
Langue:Inglês
Publié: 2018
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7294509/
https://ncbi.nlm.nih.gov/pubmed/30080238
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bjh.15515
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