Targeting CD38 with daratumumab is lethal to Waldenström macroglobulinaemia cells

CD38 is expressed on Waldenström macroglobulinaemia (WM) cells, but its role as a therapeutic target remains undefined. With recent approval of the anti-CD38 monoclonal antibody, daratumumab (Dara), we hypothesized that blocking CD38 would be lethal to WM cells. In vitro Dara treatment of WM cells (...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Br J Haematol
Prif Awduron: Paulus, Aneel, Manna, Alak, Akhtar, Sharoon, Paulus, Shumail M., Sharma, Mayank, Coignet, Marie V., Jiang, Liuyan, Roy, Vivek, Witzig, Thomas E., Ansell, Stephen M., Allan, John, Furman, Richard, Aulakh, Sonikpreet, Manochakian, Rami, Ailawadhi, Sikander, Chanan-Khan, Asher A., Sher, Taimur
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2018
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7294509/
https://ncbi.nlm.nih.gov/pubmed/30080238
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bjh.15515
Tagiau: Ychwanegu Tag
Dim Tagiau, Byddwch y cyntaf i dagio'r cofnod hwn!

Eitemau Tebyg