Antibody-targeted interleukin 2 stimulates T-cell killing of autologous tumor cells.

A genetically engineered fusion protein consisting of a chimeric anti-ganglioside GD2 antibody (ch14.18) and interleukin 2 (IL2) was tested for its ability to enhance the killing of autologous GD2-expressing melanoma target cells by a tumor-infiltrating lymphocyte line (660 TIL). The fusion of IL2 t...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Gillies, S D, Reilly, E B, Lo, K M, Reisfeld, R A
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1992
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC48464/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1741398/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.89.4.1428
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