Serum half-life and tumor localization of a chimeric antibody deleted of the CH2 domain and directed against the disialoganglioside GD2.

Recombinant techniques allow one to engineer an antibody molecule and, in this way, manipulate its properties and functions. We engineered a chimeric human/mouse antibody to the tumor-associated antigen ganglioside GD2, with the aim of decreasing its serum half-life, maintaining its full antigen-bin...

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Publikašuvnnas:	Proc Natl Acad Sci U S A
Váldodahkkit:	Mueller, B M, Reisfeld, R A, Gillies, S D
Materiálatiipa:	Artigo
Giella:	Inglês
Almmustuhtton:	National Academy of Sciences 1990
Fáttát:	Research Article
Liŋkkat:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC54395/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2198570/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.87.15.5702
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