Paradoxical Increase in Mortality and Rupture of Intracranial Aneurysms in mPGES-1 Deficient Mice: Attenuation by Aspirin

BACKGROUND: Inflammation plays an important role in formation and rupture of intracranial aneurysms. Expression of microsomal prostaglandin E(2) (PGE(2)) synthase type 1 (mPGES-1) is increased in the wall of intracranial aneurysms in humans. PGE(2), a by-product of mPGES-1, is associated with inflam...

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Bibliografske podrobnosti
izdano v:Neurosurgery
Main Authors: Peña Silva, Ricardo A., Mitchell, Ian J, Kung, David K, Pewe, Lecia L., Granja, Manuel F, Harty, John T, Faraci, Frank M., Heistad, Donald D, Hasan, David M
Format: Artigo
Jezik:Inglês
Izdano: 2015
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4846385/
https://ncbi.nlm.nih.gov/pubmed/26134597
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1227/NEU.0000000000000883
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