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Paradoxical Increase in Mortality and Rupture of Intracranial Aneurysms in mPGES-1 Deficient Mice: Attenuation by Aspirin
BACKGROUND: Inflammation plays an important role in formation and rupture of intracranial aneurysms. Expression of microsomal prostaglandin E(2) (PGE(2)) synthase type 1 (mPGES-1) is increased in the wall of intracranial aneurysms in humans. PGE(2), a by-product of mPGES-1, is associated with inflam...
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| Publicado no: | Neurosurgery |
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| Main Authors: | , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4846385/ https://ncbi.nlm.nih.gov/pubmed/26134597 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1227/NEU.0000000000000883 |
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