Hmga1 null mouse embryonic fibroblasts display downregulation of spindle assembly checkpoint gene expression associated to nuclear and karyotypic abnormalities

The High Mobility Group A1 proteins (HMGA1) are nonhistone chromatinic proteins with a critical role in development and cancer. We have recently reported that HMGA1 proteins are able to increase the expression of spindle assembly checkpoint (SAC) genes, thus impairing SAC function and causing chromo...

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Publié dans:Cell Cycle
Auteurs principaux: Pierantoni, Giovanna Maria, Conte, Andrea, Rinaldo, Cinzia, Tornincasa, Mara, Gerlini, Raffaele, Valente, Davide, Izzo, Antonella, Fusco, Alfredo
Format: Artigo
Langue:Inglês
Publié: Taylor & Francis 2016
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Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4845974/
https://ncbi.nlm.nih.gov/pubmed/26889953
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15384101.2016.1146835
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