A proactive role of water molecules in acceptor recognition by Protein-O-fucosyltransferase 2

Protein O-fucosyltransferase 2 (POFUT2) is an essential enzyme that fucosylates serine/threonine residues of folded thrombospondin type 1 repeats (TSRs). To date, the mechanism by which this enzyme recognizes very dissimilar TSRs remained unclear. By engineering of a fusion protein, we report the cr...

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Publicado no:Nat Chem Biol
Main Authors: Valero-González, Jessika, Leonhard-Melief, Christina, Lira-Navarrete, Erandi, Jiménez-Osés, Gonzalo, Hernández-Ruiz, Cristina, Pallarés, María Carmen, Yruela, Inmaculada, Vasudevan, Deepika, Lostao, Anabel, Corzana, Francisco, Takeuchi, Hideyuki, Haltiwanger, Robert S., Hurtado-Guerrero, Ramon
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4845761/
https://ncbi.nlm.nih.gov/pubmed/26854667
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.2019
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