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Characterizing the Epothilone Binding Site on β-Tubulin by Photoaffinity Labeling: Identification of β-Tubulin Peptides TARGSQQY and TSRGSQQY as Targets of an Epothilone Photoprobe for Polymerized Tubulin

Photoaffinity labeling with an epothilone A photoprobe led to the identification of the β-tubulin peptides TARGSQQY and TSRGSQQY as targets of the photoprobe for polymerized tubulin. These peptides represent residues 274–281 in different β-tubulin isotypes. Placing the carbene producing 21-diazo/tri...

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Foilsithe in:J Med Chem
Main Authors: Ranade, Adwait R., Higgins, LeeAnn, Markowski, Todd W., Glaser, Nicole, Kashin, Dmitry, Bai, Ruoli, Hong, Kwon Ho, Hamel, Ernest, Höfle, Gerhard, Georg, Gunda I.
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2016
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4845752/
https://ncbi.nlm.nih.gov/pubmed/26986898
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.6b00188
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