Activated Notch counteracts Ikaros tumor suppression in mouse and human T-cell acute lymphoblastic leukemia

Activating NOTCH1 mutations occur in ~ 60% of human T-cell acute lymphoblastic leukemias (T-ALLs), and mutations disrupting the transcription factor IKZF1 (IKAROS) occur in ~5% of cases. To investigate the regulatory interplay between these driver genes, we have used a novel transgenic RNA interfere...

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Publicado no:Leukemia
Main Authors: Witkowski, MT, Cimmino, L, Hu, Y, Trimarchi, T, Tagoh, H, McKenzie, MD, Best, SA, Tuohey, L, Willson, TA, Nutt, SL, Busslinger, M, Aifantis, I, Smyth, GK, Dickins, RA
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4845663/
https://ncbi.nlm.nih.gov/pubmed/25655195
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/leu.2015.27
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