Pax5 loss imposes a reversible differentiation block in B-progenitor acute lymphoblastic leukemia

Loss-of-function mutations in hematopoietic transcription factors including PAX5 occur in most cases of B-progenitor acute lymphoblastic leukemia (B-ALL), a disease characterized by the accumulation of undifferentiated lymphoblasts. Although PAX5 mutation is a critical driver of B-ALL development in...

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Detalhes bibliográficos
Main Authors: Liu, Grace J., Cimmino, Luisa, Jude, Julian G., Hu, Yifang, Witkowski, Matthew T., McKenzie, Mark D., Kartal-Kaess, Mutlu, Best, Sarah A., Tuohey, Laura, Liao, Yang, Shi, Wei, Mullighan, Charles G., Farrar, Michael A., Nutt, Stephen L., Smyth, Gordon K., Zuber, Johannes, Dickins, Ross A.
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2014
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4066403/
https://ncbi.nlm.nih.gov/pubmed/24939936
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.240416.114
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