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Chloroquine anticancer activity is mediated by autophagy-independent effects on the tumor vasculature

Chloroquine is used clinically as an autophagy blocker to potentiate anticancer treatments. However, whether chloroquine acts solely through autophagy-dependent and cancer cell autonomous mechanisms has remained elusive. In a recent study we found that chloroquine reduced intratumoral hypoxia and me...

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Publicat a:Mol Cell Oncol
Autors principals: Maes, Hannelore, Kuchnio, Anna, Carmeliet, Peter, Agostinis, Patrizia
Format: Artigo
Idioma:Inglês
Publicat: Taylor & Francis 2015
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4845249/
https://ncbi.nlm.nih.gov/pubmed/27308577
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/23723548.2014.970097
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