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Unanticipated role of melanin in causing carcinogenic cyclobutane pyrimidine dimers

Ultraviolet radiation (UVR) instantaneously generates cyclobutane pyrimidine dimers (CPDs). Paradoxically, we recently observed that UV enables the protective pigment melanin to create CPDs in the dark long after the exposure ends. UV-induced reactive oxygen species (ROS) oxidize melanin to create m...

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Publicat a:Mol Cell Oncol
Autors principals: Premi, Sanjay, Brash, Douglas E.
Format: Artigo
Idioma:Inglês
Publicat: Taylor & Francis 2015
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4845191/
https://ncbi.nlm.nih.gov/pubmed/27308551
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/23723556.2015.1033588
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