Loading...
Point mutations in the tumor suppressor Smad4/DPC4 enhance its phosphorylation by GSK3 and reversibly inactivate TGF-β signaling
The tumor suppressor Smad4/DPC4 is an essential transcription factor in the TGF-β pathway and is frequently mutated or deleted in prostate, colorectal, and pancreatic carcinomas. We recently discovered that Smad4 activity and stability are regulated by the FGF/EGF and Wnt signaling pathways through...
Saved in:
| Published in: | Mol Cell Oncol |
|---|---|
| Main Authors: | , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
Taylor & Francis
2015
|
| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4845174/ https://ncbi.nlm.nih.gov/pubmed/27308538 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/23723556.2015.1025181 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|