Adipose tissue mTORC2 regulates ChREBP-driven de novo lipogenesis and hepatic glucose metabolism

Adipose tissue de novo lipogenesis (DNL) positively influences insulin sensitivity, is reduced in obesity, and predicts insulin resistance. Therefore, elucidating mechanisms controlling adipose tissue DNL could lead to therapies for type 2 diabetes. Here, we report that mechanistic target of rapamyc...

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Veröffentlicht in:Nat Commun
Hauptverfasser: Tang, Yuefeng, Wallace, Martina, Sanchez-Gurmaches, Joan, Hsiao, Wen-Yu, Li, Huawei, Lee, Peter L., Vernia, Santiago, Metallo, Christian M., Guertin, David A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2016
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4844681/
https://ncbi.nlm.nih.gov/pubmed/27098609
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms11365
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