Brown fat AKT2 is a cold-induced kinase that stimulates ChREBP-mediated de novo lipogenesis to optimize fuel storage and thermogenesis

Brown adipose tissue (BAT) is a therapeutic target for metabolic diseases; thus, understanding its metabolic circuitry is clinically important. Many studies of BAT compare rodents mildly cold to those severely cold. Here, we compared BAT remodeling between thermoneutral and mild cold adapted mice, c...

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Veröffentlicht in:Cell Metab
Hauptverfasser: Sanchez-Gurmaches, Joan, Tang, Yuefeng, Jespersen, Naja Zenius, Wallace, Martina, Calejman, Camila Martinez, Gujja, Sharvari, Li, Huawei, Edwards, Yvonne JK, Wolfrum, Christian, Metallo, Christian M, Nielsen, Søren, Scheele, Camilla, Guertin, David A
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2017
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5762420/
https://ncbi.nlm.nih.gov/pubmed/29153407
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2017.10.008
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