Profiling serum bile acid glucuronides in humans: gender divergences, genetic determinants and response to fenofibrate

Glucuronidation, catalyzed by UDP-glucuronosyltransferase (UGT) enzymes detoxifies cholestatic bile acids (BAs). We aimed at i) characterizing the circulating BA-glucuronide (-G) pool composition in humans, ii) evaluating how sex and UGT polymorphisms influence this composition, and iii) analyzing t...

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Detalhes bibliográficos
Publicado no:Clin Pharmacol Ther
Main Authors: Trottier, Jocelyn, Perreault, Martin, Rudkowska, Iwona, Levy, Cynthia, Dallaire-Theroux, Amélie, Verreault, Mélanie, Caron, Patrick, Staels, Bart, Vohl, Marie-Claude, Straka, Robert J., Barbier, Olivier
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4844538/
https://ncbi.nlm.nih.gov/pubmed/23756370
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/clpt.2013.122
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