HDAC 3-selective inhibitor RGFP966 demonstrates anti-inflammatory properties in RAW 264.7 macrophages and mouse precision-cut lung slices by attenuating NF-κB p65 transcriptional activity

The increasing number of patients suffering from chronic obstructive pulmonary disease (COPD) represents a major and increasing health problem. Therefore, novel therapeutic approaches are needed. Class I HDACs 1, 2 and 3 play key roles in the regulation of inflammatory gene expression with a particu...

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Veröffentlicht in:Biochem Pharmacol
Hauptverfasser: Leus, Niek G.J., van der Wouden, Petra E., van den Bosch, Thea, Hooghiemstra, Wouter T.R., Ourailidou, Maria E., Kistemaker, Loes E.M., Bischoff, Rainer, Gosens, Reinoud, Haisma, Hidde J., Dekker, Frank J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Elsevier Science 2016
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4844503/
https://ncbi.nlm.nih.gov/pubmed/26993378
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bcp.2016.03.010
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