The Tribbles 2 (TRB2) pseudokinase binds to ATP and autophosphorylates in a metal-independent manner

The human Tribbles (TRB)-related pseudokinases are CAMK (calcium/calmodulin-dependent protein kinase)-related family members that have evolved a series of highly unusual motifs in the ‘pseudocatalytic’ domain. In canonical kinases, conserved amino acids bind to divalent metal ions and align ATP prio...

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發表在:Biochem J
Main Authors: Bailey, Fiona P., Byrne, Dominic P., Oruganty, Krishnadev, Eyers, Claire E., Novotny, Christopher J., Shokat, Kevan M., Kannan, Natarajan, Eyers, Patrick A.
格式: Artigo
語言:Inglês
出版: 2015
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4844368/
https://ncbi.nlm.nih.gov/pubmed/25583260
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20141441
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