Elucidating the Mechanism by which Compensatory Mutations Rescue an HIV-1 Matrix Mutant Defective for Gag Membrane Targeting and Envelope Glycoprotein Incorporation

The matrix (MA) domain of the HIV-1 Gag is responsible for Gag targeting to the plasma membrane where virions assemble. MA also plays a role in the incorporation of the viral envelope (Env) glycoproteins, and can influence particle infectivity post-maturation and post-entry. A highly basic region of...

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Vydáno v:J Mol Biol
Hlavní autoři: Tedbury, Philip R., Mercredi, Peter Y., Gaines, Christy R., Summers, Michael F., Freed, Eric O.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2015
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4844178/
https://ncbi.nlm.nih.gov/pubmed/25659909
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2015.01.018
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