HIV-1 Matrix Trimerization-Impaired Mutants Are Rescued by Matrix Substitutions That Enhance Envelope Glycoprotein Incorporation

The matrix (MA) domain of HIV-1 Gag plays key roles in virus assembly by targeting the Gag precursor to the plasma membrane and directing the incorporation of the viral envelope (Env) glycoprotein into virions. The latter function appears to be in part dependent on trimerization of the MA domain of...

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Bibliografiske detaljer
Udgivet i:J Virol
Main Authors: Tedbury, Philip R., Novikova, Mariia, Alfadhli, Ayna, Hikichi, Yuta, Kagiampakis, Ioannis, KewalRamani, Vineet N., Barklis, Eric, Freed, Eric O.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2019
Fag:
Structure and Assembly
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6912099/
https://ncbi.nlm.nih.gov/pubmed/31619553
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01526-19
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