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Platelet-activating factor is a potent pyrogen and cryogen, but it does not mediate lipopolysaccharide fever or hypothermia
We examined whether platelet-activating factor (PAF) and its receptor mediate lipopolysaccharide (LPS)-induced fever and hypothermia in rats. Two highly potent, structurally distinct antagonists of the PAF receptor, CV6209 and WEB2086, were used. At a neutral ambient temperature (T(a)) of 30ºC, admi...
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| Udgivet i: | Temperature (Austin) |
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| Main Authors: | , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Taylor & Francis
2015
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4843927/ https://ncbi.nlm.nih.gov/pubmed/27227073 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/23328940.2015.1030540 |
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