Transient Hepatic Overexpression of Insulin-Like Growth Factor 2 Induces Free Cholesterol and Lipid Droplet Formation

Although insulin-like growth factor 2 (IGF2) has been reported to be overexpressed in steatosis and steatohepatitis, a causal role of IGF2 in steatosis development remains elusive. Aim of our study was to decipher the role of IGF2 in steatosis development. Hydrodynamic gene delivery of an Igf2 plasm...

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Veröffentlicht in:Front Physiol
Hauptverfasser: Kessler, Sonja M., Laggai, Stephan, Van Wonterghem, Elien, Gemperlein, Katja, Müller, Rolf, Haybaeck, Johannes, Vandenbroucke, Roosmarijn E., Ogris, Manfred, Libert, Claude, Kiemer, Alexandra K.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2016
Schlagworte:
Physiology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4843762/
https://ncbi.nlm.nih.gov/pubmed/27199763
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphys.2016.00147
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