Incidental germline variants in 1000 advanced cancers on a prospective somatic genomic profiling protocol

BACKGROUND: Next-generation sequencing in cancer research may reveal germline variants of clinical significance. We report patient preferences for return of results and the prevalence of incidental pathogenic germline variants (PGVs). PATIENTS AND METHODS: Targeted exome sequencing of 202 genes was...

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Bibliografiske detaljer
Udgivet i:Ann Oncol
Main Authors: Meric-Bernstam, F., Brusco, L., Daniels, M., Wathoo, C., Bailey, A. M., Strong, L., Shaw, K., Lu, K., Qi, Y., Zhao, H., Lara-Guerra, H., Litton, J., Arun, B., Eterovic, A. K., Aytac, U., Routbort, M., Subbiah, V., Janku, F., Davies, M. A., Kopetz, S., Mendelsohn, J., Mills, G. B., Chen, K.
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2016
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Original Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4843184/
https://ncbi.nlm.nih.gov/pubmed/26787237
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/annonc/mdw018
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