Telomerase Inhibition by Everolimus Suppresses Smooth Muscle Cell Proliferation and Neointima Formation Through Epigenetic Gene Silencing

Proliferation of smooth muscle cells (SMCs) during neointima formation is prevented by drug-eluting stents. The replicative capacity of mammalian cells is enhanced by telomerase expression; however, the contribution of telomerase to the proliferative response underlying neointima formation and its p...

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Detalhes bibliográficos
Publicado no:JACC Basic Transl Sci
Main Authors: Aono, Jun, Ruiz-Rodriguez, Ernesto, Qing, Hua, Findeisen, Hannes M., Jones, Karrie L., Heywood, Elizabeth B., Bruemmer, Dennis
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2016
Assuntos:
PRE-CLINICAL RESEARCH
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4843168/
https://ncbi.nlm.nih.gov/pubmed/27127803
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jacbts.2016.01.002
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