The PPARα/p16(INK4a) Pathway inhibits Vascular Smooth Muscle Cell Proliferation by repressing Cell Cycle-dependent Telomerase Activation

Peroxisome Proliferator-Activated Receptor (PPAR) α, the molecular target for fibrates used to treat dyslipidemia, exerts pleiotropic effects on vascular cells. In vascular smooth muscle cells (VSMCs), we have previously demonstrated that PPARα activation suppresses G(1)→S cell cycle progression by...

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Huvudupphovsmän: Gizard, Florence, Nomiyama, Takashi, Zhao, Yue, Findeisen, Hannes M., Heywood, Elizabeth B., Jones, Karrie L., Staels, Bart, Bruemmer, Dennis
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2008
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2756491/
https://ncbi.nlm.nih.gov/pubmed/18818403
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.108.186205
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