Preclinical efficacy of the MDM2 inhibitor RG7112 in MDM2 amplified and TP53 wild-type glioblastomas

RATIONALE: p53 pathway alterations are key molecular events in glioblastoma (GBM). MDM2 inhibitors increase expression and stability of p53 and are presumed to be most efficacious in patients with TP53 wild-type and MDM2-amplified cancers. However, this biomarker hypothesis has not been tested in pa...

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Veröffentlicht in:Clin Cancer Res
Hauptverfasser: Verreault, Maite, Schmitt, Charlotte, Goldwirt, Lauriane, Pelton, Kristine, Haidar, Samer, Levasseur, Camille, Guehennec, Jeremy, Knoff, David, Labussiere, Marianne, Marie, Yannick, Ligon, Azra H., Mokhtari, Karima, Hoang-Xuan, Khe, Sanson, Marc, Alexander, Brian M, Wen, Patrick Y., Delattre, Jean-Yves, Ligon, Keith L., Idbaih, Ahmed
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2015
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4842012/
https://ncbi.nlm.nih.gov/pubmed/26482041
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-15-1015
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