Synthesis and pharmacological evaluation of mono-arylimidamides as antileishmanial agents

Arylimidamide (AIA) compounds containing two pyridylimidamide terminal groups (bis-AIAs) possess outstanding in vitro antileishmanial activity, and the frontrunner bis-AIA DB766 (2,5-bis[2-(2-isopropoxy)-4-(2-pyridylimino)aminophenyl]furan) is active in visceral leishmaniasis models when given orall...

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Bibliografiske detaljer
Udgivet i:Bioorg Med Chem Lett
Main Authors: Zhu, Xiaohua, Farahat, Abdelbasset A., Mattamana, Meena, Joice, April, Pandharkar, Trupti, Holt, Elizabeth, Banerjee, Moloy, Gragg, Jamie L., Hu, Laixing, Kumar, Arvind, Yang, Sihyung, Wang, Michael Zhuo, Boykin, David W., Werbovetz, Karl A.
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier Science Ltd 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4841789/
https://ncbi.nlm.nih.gov/pubmed/27048943
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2016.03.082
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