Synthesis and pharmacological evaluation of mono-arylimidamides as antileishmanial agents

Arylimidamide (AIA) compounds containing two pyridylimidamide terminal groups (bis-AIAs) possess outstanding in vitro antileishmanial activity, and the frontrunner bis-AIA DB766 (2,5-bis[2-(2-isopropoxy)-4-(2-pyridylimino)aminophenyl]furan) is active in visceral leishmaniasis models when given orall...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Bioorg Med Chem Lett
Prif Awduron: Zhu, Xiaohua, Farahat, Abdelbasset A., Mattamana, Meena, Joice, April, Pandharkar, Trupti, Holt, Elizabeth, Banerjee, Moloy, Gragg, Jamie L., Hu, Laixing, Kumar, Arvind, Yang, Sihyung, Wang, Michael Zhuo, Boykin, David W., Werbovetz, Karl A.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Elsevier Science Ltd 2016
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4841789/
https://ncbi.nlm.nih.gov/pubmed/27048943
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2016.03.082
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